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GMP-compliant cannabinoid based therapeutic actives

Medical Cannabis Extraction

There are worldwide rules controlling residual solvents in medicines. The alcohol solvent used in medicinal cannabis extraction, often ethanol, “dissolves” the plant material. The liquid is then frequently filtered before the alcohol is eventually eliminated by evaporation [1]. The intrinsic polarity of these solvents, which means they have a propensity to combine with water and […]

A Deep Dive Into Dronabinol

Dronabinol ((-)-trans-delta-9-tetrahydrocannabinol), is the registered API name for THC naturally present in botanical cannabis (Cannabis sativa L.). The pharmacological actions of dronabinol are modulated by other cannabinoids found in the cannabis plant. Dronabinol preparations can be injected intravenously, topically, or by transdermal delivery methods and taken orally (oral, sublingual, or buccal). The molecule of dronabinol […]

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CBD Isolate Natural

Parameters	Specification
Formulation	>98% CBD
Appearance	White crystalline powder
Packaging	1kg HDPE container
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Ethanol
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Distillate + Strain-Specific Terpenes

Parameters	Specification
Formulation	440mg (0.5ml) or 880mg (1ml) THC distillate + Chemotype terpenes
Appearance	Yellow-gold viscous liquid, solid at room temperature
Packaging	1ml SS316 510-Thread cartridge 0.5ml SS316 510-Thread cartridge
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	18 months (on-going)
Extraction	Cryo-ethanol extraction Low temperature Decarboxylation to preserve terpenes
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 18 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	"Day Blend", "Night Blend", UK Cheese, Blueberry Kush, Black Cherry Punch, Royal Gorilla, Karels Haze, Critical Kush, Creamy Kees, White Lemon, Original Blitz, Sour OG Cheese, Mandarin Cookies, Jungle Pie, Slurricane, Gooseberry Pie

Distillate + Botanical Terpenes

Parameters	Specification
Formulation	440mg (0.5ml) or 880mg (1ml) THC distillate + Botanical terpenes and/or Flavours
Appearance	Yellow-gold viscous liquid, solid at room temperature
Packaging	1ml SS316 510-Thread cartridge 0.5ml SS316 510-Thread cartridge
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	18 months (on-going)
Extraction	Cryo-ethanol extraction Low temperature Decarboxylation to preserve terpenes
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 18 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Options	Blueberry Haze, Grape, Blue Dream, Orange, GG#4 (Live Resin)

Live Rosin Strain Specific

Parameters	Specification
Formulation	375mg (0.5ml) or 750mg (1ml) THC Live Rosin
Appearance	Yellow-gold viscous liquid, solid at room temperature
Packaging	1ml SS316 510-Thread Cartridge 0.5ml SS316 510-Thread Cartridge
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	18 months (on-going)
Extraction	EP-grade water and low temperature pressing, fresh frozen cannabis flower
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 18 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	GMO Cookies, Wedding Cake, Guerilla Cookies, Platinum Slurricane, Duraflame, East Coast Sour Diesel, Ice Box, Stawguava, Cheetah Piss, Moonshine Haze

Live Resin Strain Specific

Parameters	Specification
Formulation	440mg (0.5ml) or 880mg (1ml) THC Live Resin
Appearance	Yellow-gold viscous liquid, solid at room temperature
Packaging	1ml All-Ceramic 510-Thread Cartridge 0.5ml All-Ceramic 510-Thread Cartridge
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	18 months (on-going)
Extraction	Low temperature hydrocarbon, fresh frozen cannabis flower
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 18 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	Sour Tangie, OG Kush, Apes in Space

Full-Spectrum Decarboxylated Crude Oil

Parameters	Specification
Formulation	>70% THC <2% CBD
Appearance	Dark Amber liquid, solid at room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Cryo-ethanol extraction Low temperature Decarboxylation to preserve terpenes
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	Black Cherry Punch (Hybrid-Indica), Blueberry Kush (Indica), Critical Kush (Indica), Creamy Kees (Hybrid-Indica), Royal Go- rilla (Hybrid-Sativa), Karel’s Haze (Hybrid-Sativa), Bafokeng Choice-White Lemon (Hybrid-Sativa), UK Cheese (Sativa), Original Blitz (Indica) \| *More strains on request

Broad-Spectrum Distillate

Parameters	Specification
Formulation	>88% THC <2% CBD
Appearance	Clear yellow-gold viscous liquid, solid at room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Cryo-ethanol extraction Low temperature Decarboxylation to preserve terpenes
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	Black Cherry Punch (Hybrid-Indica), Blueberry Kush (Indica), Critical Kush (Indica), Creamy Kees (Hybrid-Indica), Royal Go- rilla (Hybrid-Sativa), Karel’s Haze (Hybrid-Sativa), Bafokeng Choice-White Lemon (Hybrid-Sativa), UK Cheese (Sativa), Original Blitz (Indica)\| More strains on request

Live Rosin

Parameters	Specification
Formulation	>70% THC <2% CBD
Appearance	Viscous semi-solid at room temperature, yellow-gold
Packaging	Insert Argon purged. Amber glass bottle 5ml, 50ml, 250ml. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Low temperature EP-grade water, fresh frozen cannabis
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	GMO Cookies, Wedding Cake, Guerilla Cookies, Platinum Slurricane, Duraflame, East Coast Sour Diesel, Ice Box, Stawguava, Cheetah Piss, Moonshine Haze

Live Resin

Parameters	Specification
Formulation	> 85% THC <2% THC
Appearance	Yellow-gold, semi-solid at room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Low temperature hydrocarbon, fresh frozen cannabis flower
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	Sour Tangie, OG Kush, Apes in Space

D9-THC API (95+%) Natural

Parameters	Specification
Formulation	> 95% THC, minors according to pharmaceutical monograph
Product Type	API
Appearance	Clear viscous liquid, solid at room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Solvent extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 12 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

CBD Dominant

100mg/ml CBD <4mg/ml THC – 30ml

Parameters	Specification
Formulation	Full spectrum CBD extract with pharma grade MCT oil
Product Type	MCT oral formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber dropper bottle with a child-resistant lid and syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

CBD Dominant

200mg/ml CBD <4mg/ml THC – 30ml

Parameters	Specification
Formulation	Full spectrum CBD extract with pharma grade MCT oil
Product Type	MCT oral formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber dropper bottle with a child-resistant lid and syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

CBD Dominant

200mg/ml CBD <ND THC – 30ml

Parameters	Specification
Formulation	CBD isolate with pharma grade MCT oil
Product Type	MCT oral formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber bottle with glass pipette dropper
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Balanced

15mg/ml CBD – 15mg/ml THC – 30ml

Parameters	Specification
Formulation	Full spectrum THC and CBD extract with pharma grade MCT oil
Product Type	Oral MCT formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber bottle with child-resistant lid and 1ml syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Balanced

25mg/ml CBD – 25mg/ml THC – 30ml

Parameters	Specification
Formulation	Full spectrum THC and CBD extract with pharma grade MCT oil
Product Type	Oral MCT formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber bottle with child-resistant lid and 1ml syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

THC Dominant

<1mg/ml CBD -15mg/ml THC – 50ml

Parameters	Specification
Formulation	Full spectrum THC extract with pharma grade MCT oil
Product Type	Oral MCT formulation
Appearance	Clear viscous liquid, solid a room temperature
Packaging	50ml amber bottle with child-resistant lid and 1ml syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

THC Dominant

<1mg/ml CBD – 25mg/ml THC – 30ml

Parameters	Specification
Formulation	> 95% THC, minors according to DAC monograph
Product Type	DAC Dronabinol in oily base, MCT-oil formulated according to NRF 22.8
Appearance	Clear viscous liquid, solid a room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction Chromatography purification
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

THC Solution 25mg/ml

Parameters	Specification
Product Type	Purified THC in oily base, MCT-Oil
Formulation	25mg/ml THC
Appearance	Clear, almost colourless to slightly yellowish viscous solution
Packaging	50ml, 200ml or 500ml amber glass jar Type III, white CR screw cap, magisterial preparation format with TE cap (PP), 2 x THC strip, reaction tube, sterile pipett
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	Ongoing - expected 12 months
Extraction	Solvent extraction and formulation
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Category: Articles

Medical Cannabis Extraction

A Deep Dive Into Dronabinol