GMP-compliant cannabinoid based therapeutic actives

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Company Updates

GES Monthly Newsletter, January 2024

February 20, 2024

GES is excited to start the year with a bolstered product catalog with new products entering our approach offering to our clients (please download our latest product catalog here). We have already firmed up supply relationships, particularly in Australia, Germany, and the UK.

Our new offering for 2024 will be launching throughout Q2 of 2024 and includes a bolstered scaled supply chain of:

Bulk or Packed Cannabis Flower
THC Crude Oil
THC Distillate
Live Rosin
Live Resin
DAC Dronabinol: Bulk, Syringes, Oral Formulation 50ml
Vape Cartridges: Distillate, Live Rosin, and Live Resin
Oral Formulations: 200mg/ml CBD Isolate 30ml, 200mg/ml CBD Full-Spectrum 30ml, 25mg/ml CBD 25mg/ml THC 30ml, 15mg/ml THC 50ml
Concentrates: 5g Live Hash/Temple Ball, 2g Live Rosin, 3g Live Resin

If you would like to receive samples for our products above, please enquire here.

Firstly, GES has entered into partnerships that will see an exciting development into placing a water-based (solventless) full-spectrum cannabis extract or “live rosin”. This novel active cannabinoid ingredient with innovative terpene and flavor characteristics will be available for compounding use cases, vape cartridges, and oral formulations. Our key value chain partnerships will be bolstering large quantities with the initial goal of producing min. 200 kgs of “live rosin” extract for the global medical cannabis market in 2024.

GES – Live Rosin full-spectrum vape cartridge

GES selected chemotype, Platinum Slurricance – fresh frozen extraction flowers

Our 12-month research and development programs have brought to market scaled supply chains of the most innovative, unique, and active-containing constituents for our clients this year.

We are also extremely excited about some breakthroughs in our value chain about the manufacture of DAC Dronabinol. Putting together a scalable validated manufacturing process for high purity, 98+%, APIs from natural sources, especially when the API is oxidized in the presence of air has proven to be a difficult task and a long journey. However, we are extremely excited about the recent breakthrough that will allow us to dig further into the world of registered generic APIs, particularly natural Dronabinol. This new validated process and products will be used as our base going into 2024 for an APIMF (Active Pharmaceutical Ingredient Master File) submission later this year, allowing us to register this API with our regulator, SAHPRA. This API is available for sale as a GMP Part 2 raw material and we are actively looking for partners in the fields of generic drug registration, clinical trials and university research and development. Please reach out for a sample today.

In preparation for a prosperous year at GES, January has been spent meticulously taking apart our technologies and performing a thorough deep routine maintenance as well as upgrading our existing utilities (heating/cooling) to provide larger capacities for API manufacturing as well as performing operational qualifications and stability batches for our new product launches in 2024.

GES – Stability Chambers packed with new products for 2024

As always, if you are looking for a partner that has a stable, scalable, and reliable value chain and technology platform – please feel free to contact us and find out more information from us.

We provide the best form of medicinal cannabis products, today, tomorrow, and well into the future.

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GES Monthly Newsletter, Quarter 3 (July – September) 2024

September 15, 2024

Pioneering Solventless Production

September 15, 2024

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Specialized biotech company providing therapeutic actives derived from cannabinoids found in medical cannabis.

CBD Isolate Natural

Parameters	Specification
Formulation	>98% CBD
Appearance	White crystalline powder
Packaging	1kg HDPE container
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Ethanol
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Distillate + Strain-Specific Terpenes

Parameters	Specification
Formulation	440mg (0.5ml) or 880mg (1ml) THC distillate + Chemotype terpenes
Appearance	Yellow-gold viscous liquid, solid at room temperature
Packaging	1ml SS316 510-Thread cartridge 0.5ml SS316 510-Thread cartridge
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	18 months (on-going)
Extraction	Cryo-ethanol extraction Low temperature Decarboxylation to preserve terpenes
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 18 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	"Day Blend", "Night Blend", UK Cheese, Blueberry Kush, Black Cherry Punch, Royal Gorilla, Karels Haze, Critical Kush, Creamy Kees, White Lemon, Original Blitz, Sour OG Cheese, Mandarin Cookies, Jungle Pie, Slurricane, Gooseberry Pie

Distillate + Botanical Terpenes

Parameters	Specification
Formulation	440mg (0.5ml) or 880mg (1ml) THC distillate + Botanical terpenes and/or Flavours
Appearance	Yellow-gold viscous liquid, solid at room temperature
Packaging	1ml SS316 510-Thread cartridge 0.5ml SS316 510-Thread cartridge
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	18 months (on-going)
Extraction	Cryo-ethanol extraction Low temperature Decarboxylation to preserve terpenes
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 18 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Options	Blueberry Haze, Grape, Blue Dream, Orange, GG#4 (Live Resin)

Live Rosin Strain Specific

Parameters	Specification
Formulation	375mg (0.5ml) or 750mg (1ml) THC Live Rosin
Appearance	Yellow-gold viscous liquid, solid at room temperature
Packaging	1ml SS316 510-Thread Cartridge 0.5ml SS316 510-Thread Cartridge
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	18 months (on-going)
Extraction	EP-grade water and low temperature pressing, fresh frozen cannabis flower
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 18 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	GMO Cookies, Wedding Cake, Guerilla Cookies, Platinum Slurricane, Duraflame, East Coast Sour Diesel, Ice Box, Stawguava, Cheetah Piss, Moonshine Haze

Live Resin Strain Specific

Parameters	Specification
Formulation	440mg (0.5ml) or 880mg (1ml) THC Live Resin
Appearance	Yellow-gold viscous liquid, solid at room temperature
Packaging	1ml All-Ceramic 510-Thread Cartridge 0.5ml All-Ceramic 510-Thread Cartridge
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	18 months (on-going)
Extraction	Low temperature hydrocarbon, fresh frozen cannabis flower
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 18 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	Sour Tangie, OG Kush, Apes in Space

Full-Spectrum Decarboxylated Crude Oil

Parameters	Specification
Formulation	>70% THC <2% CBD
Appearance	Dark Amber liquid, solid at room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Cryo-ethanol extraction Low temperature Decarboxylation to preserve terpenes
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	Black Cherry Punch (Hybrid-Indica), Blueberry Kush (Indica), Critical Kush (Indica), Creamy Kees (Hybrid-Indica), Royal Go- rilla (Hybrid-Sativa), Karel’s Haze (Hybrid-Sativa), Bafokeng Choice-White Lemon (Hybrid-Sativa), UK Cheese (Sativa), Original Blitz (Indica) \| *More strains on request

Broad-Spectrum Distillate

Parameters	Specification
Formulation	>88% THC <2% CBD
Appearance	Clear yellow-gold viscous liquid, solid at room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Cryo-ethanol extraction Low temperature Decarboxylation to preserve terpenes
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	Black Cherry Punch (Hybrid-Indica), Blueberry Kush (Indica), Critical Kush (Indica), Creamy Kees (Hybrid-Indica), Royal Go- rilla (Hybrid-Sativa), Karel’s Haze (Hybrid-Sativa), Bafokeng Choice-White Lemon (Hybrid-Sativa), UK Cheese (Sativa), Original Blitz (Indica)\| More strains on request

Live Rosin

Parameters	Specification
Formulation	>70% THC <2% CBD
Appearance	Viscous semi-solid at room temperature, yellow-gold
Packaging	Insert Argon purged. Amber glass bottle 5ml, 50ml, 250ml. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Low temperature EP-grade water, fresh frozen cannabis
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	GMO Cookies, Wedding Cake, Guerilla Cookies, Platinum Slurricane, Duraflame, East Coast Sour Diesel, Ice Box, Stawguava, Cheetah Piss, Moonshine Haze

Live Resin

Parameters	Specification
Formulation	> 85% THC <2% THC
Appearance	Yellow-gold, semi-solid at room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Low temperature hydrocarbon, fresh frozen cannabis flower
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	Sour Tangie, OG Kush, Apes in Space

D9-THC API (95+%) Natural

Parameters	Specification
Formulation	> 95% THC, minors according to pharmaceutical monograph
Product Type	API
Appearance	Clear viscous liquid, solid at room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Solvent extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 12 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

CBD Dominant

100mg/ml CBD <4mg/ml THC – 30ml

Parameters	Specification
Formulation	Full spectrum CBD extract with pharma grade MCT oil
Product Type	MCT oral formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber dropper bottle with a child-resistant lid and syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

CBD Dominant

200mg/ml CBD <4mg/ml THC – 30ml

Parameters	Specification
Formulation	Full spectrum CBD extract with pharma grade MCT oil
Product Type	MCT oral formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber dropper bottle with a child-resistant lid and syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

CBD Dominant

200mg/ml CBD <ND THC – 30ml

Parameters	Specification
Formulation	CBD isolate with pharma grade MCT oil
Product Type	MCT oral formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber bottle with glass pipette dropper
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Balanced

15mg/ml CBD – 15mg/ml THC – 30ml

Parameters	Specification
Formulation	Full spectrum THC and CBD extract with pharma grade MCT oil
Product Type	Oral MCT formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber bottle with child-resistant lid and 1ml syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Balanced

25mg/ml CBD – 25mg/ml THC – 30ml

Parameters	Specification
Formulation	Full spectrum THC and CBD extract with pharma grade MCT oil
Product Type	Oral MCT formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber bottle with child-resistant lid and 1ml syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

THC Dominant

<1mg/ml CBD -15mg/ml THC – 50ml

Parameters	Specification
Formulation	Full spectrum THC extract with pharma grade MCT oil
Product Type	Oral MCT formulation
Appearance	Clear viscous liquid, solid a room temperature
Packaging	50ml amber bottle with child-resistant lid and 1ml syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

THC Dominant

<1mg/ml CBD – 25mg/ml THC – 30ml

Parameters	Specification
Formulation	> 95% THC, minors according to DAC monograph
Product Type	DAC Dronabinol in oily base, MCT-oil formulated according to NRF 22.8
Appearance	Clear viscous liquid, solid a room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction Chromatography purification
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

THC Solution 25mg/ml

Parameters	Specification
Product Type	Purified THC in oily base, MCT-Oil
Formulation	25mg/ml THC
Appearance	Clear, almost colourless to slightly yellowish viscous solution
Packaging	50ml, 200ml or 500ml amber glass jar Type III, white CR screw cap, magisterial preparation format with TE cap (PP), 2 x THC strip, reaction tube, sterile pipett
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	Ongoing - expected 12 months
Extraction	Solvent extraction and formulation
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

GES Monthly Newsletter, January 2024