GMP-compliant cannabinoid based therapeutic actives

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Company Updates

GES Monthly Newsletter, April 2024

April 19, 2024

Mark Gething joins to lead the team as Managing Director
Delivery of the first commercial batch of our oral formulations into partner networks following validations
Availability of premium, indoor-dried cannabis flower

April 2024

We are delighted by the progressive expansion of our enterprise and the sustained trajectory of strategic recruitment we have embarked upon. In pursuit of further advancement, we announce the appointment of Mr. Mark Gething as our new Managing Director. Mr. Gething, who commenced his tenure earlier this year, brings to our organization two decades of experience in addressing organizational challenges and orchestrating the execution of strategic initiatives within entities such as Fortune 500 companies, DIAGEO, Petronas, and Metropolitan Life. His leadership has been instrumental in directing strategy and operational functions within international skincare conglomerates, notably Union Swiss (Bio-Oil), and in spearheading ventures related to medicinal cannabis endeavors.

In April, we successfully launched our series of commercial oral sublingual oil formulations, incorporating advanced THC extracts and MCT oil to engineer a 1:1 THC-CBD composition, now accessible in our collaborative markets. Building upon our previous endeavors, last year we commenced an expansion effort and substantiated a portfolio of oral formulations (refer to: https://geslabs.com/products/#oral), presently available for procurement. Furthermore, we are poised to introduce forthcoming product development ventures later this year, wherein we aim to leverage solventless full-spectrum fresh frozen extracts (live rosin) within our formulations, underscoring our dedication to enhancing taste, potency, and market competitiveness.

In alignment with our steadfast commitment to premium product excellence and in pursuit of sourcing optimal raw materials, GES has undertaken significant endeavors to incorporate premium-grade dried cannabis flowers into our repertoire. Our selection of dried cannabis flowers encompasses meticulously cultivated indoor strains boasting THC concentrations ranging from 25% to 30%, thereby exemplifying South Africa’s dedication to delivering premium-grade dried cannabis flowers to the global marketplace. For further information regarding our premium dried cannabis flower offerings and associated options, please do not hesitate to contact us.

Please visit our newly updated website to find out more on our developments and stay up to date with our available products by downloading our product catalog from our website: www.geslabs.com.

Indoor cultivated premium dried cannabis flower, South Africa

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GES Monthly Newsletter, April 2024

April 19, 2024

GES Monthly Newsletter, January 2024

February 20, 2024

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Specialized biotech company providing therapeutic actives derived from cannabinoids found in medical cannabis.

CBD Isolate Natural

Parameters	Specification
Formulation	>98% CBD
Appearance	White crystalline powder
Packaging	1kg HDPE container
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Ethanol
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Distillate + Strain-Specific Terpenes

Parameters	Specification
Formulation	400-440/800-880 mg THC distillate + Chemovar terpene concentration
Appearance	Yellow-gold viscous liquid, solid at room temperature
Packaging	1ml SS316 or All-Ceramic 10-Thread cartridge 0.5ml SS316 or All-Ceramic 10-Thread cartridge
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12 months
Extraction	Cryo-ethanol extraction Low temperature Decarboxylation to preserve terpenes
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 12 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Distillate + Botanical Terpenes

Parameters	Specification
Formulation	400-440/800-880mg THC distillate + Botanical terpene concentration
Appearance	Yellow-gold viscous liquid, solid at room temperature
Packaging	1ml SS316 or All-Ceramic 10-Thread cartridge 0.5ml SS316 or All-Ceramic 10-Thread cartridge
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12 months
Extraction	Cryo-ethanol extraction Low temperature Decarboxylation to preserve terpenes
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 12 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Live Rosin Strain Specific

Parameters	Specification
Formulation	400/800mg THC Live Rosin concentration
Appearance	Yellow-gold viscous liquid, solid at room temperature
Packaging	1ml All-Ceramic 510-Thread Cartridge 0.5ml All-Ceramic 510-Thread Cartridge
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12 months
Extraction	EP-grade water and low temperature pressing, fresh frozen cannabis flower
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 12 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Live Resin Strain Specific

Parameters	Specification
Formulation	400/800mg THC Live Resin concentration
Appearance	Yellow-gold viscous liquid, solid at room temperature
Packaging	1ml All-Ceramic 510-Thread Cartridge 0.5ml All-Ceramic 510-Thread Cartridge
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12 months
Extraction	Low temperature hydrocarbon, fresh frozen cannabis flower
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 12 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Full-Spectrum Decarboxylated Crude Oil

Parameters	Specification
Formulation	>70% THC <2% CBD
Appearance	Dark Amber liquid, solid at room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Cryo-ethanol extraction Low temperature Decarboxylation to preserve terpenes
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	Black Cherry Punch (Hybrid-Indica), Blueberry Kush (Indica), Critical Kush (Indica), Creamy Kees (Hybrid-Indica), Royal Go- rilla (Hybrid-Sativa), Karel’s Haze (Hybrid-Sativa), Bafokeng Choice-White Lemon (Hybrid-Sativa), UK Cheese (Sativa), Original Blitz (Indica) \| *More strains on request

Full-Spectrum Distillate

Parameters	Specification
Formulation	>88% THC <2% CBD
Appearance	Clear yellow-gold viscous liquid, solid at room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Cryo-ethanol extraction Low temperature Decarboxylation to preserve terpenes
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	Black Cherry Punch (Hybrid-Indica), Blueberry Kush (Indica), Critical Kush (Indica), Creamy Kees (Hybrid-Indica), Royal Go- rilla (Hybrid-Sativa), Karel’s Haze (Hybrid-Sativa), Bafokeng Choice-White Lemon (Hybrid-Sativa), UK Cheese (Sativa), Original Blitz (Indica)\| More strains on request

Live Rosin

Parameters	Specification
Formulation	>70% THC <2% CBD
Appearance	Viscous semi-solid at room temperature, yellow-gold
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Low temperature EP-grade water, fresh frozen cannabis
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	Available on request

Live Resin

Parameters	Specification
Formulation	> 85% THC <2% THC
Appearance	Yellow-gold, semi-solid at room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	24-months (stability ongoing)
Extraction	Low temperature hydrocarbon, fresh frozen cannabis flower
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)
Strains	Available on request

D9-THC API (97+%) Natural

Parameters	Specification
Formulation	> 95% THC, minors according to DAC monograph
Product Type	Dronabinol API
Appearance	Clear viscous liquid, solid at room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Solvent extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 12 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

CBD Dominant

100mg/ml CBD <4mg/ml THC – 30ml

Parameters	Specification
Formulation	Full spectrum CBD extract with pharma grade MCT oil
Product Type	MCT oral formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber dropper bottle with a child-resistant lid and syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

CBD Dominant

200mg/ml CBD <4mg/ml THC – 30ml

Parameters	Specification
Formulation	Full spectrum CBD extract with pharma grade MCT oil
Product Type	MCT oral formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber dropper bottle with a child-resistant lid and syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

CBD Dominant

200mg/ml CBD <ND THC – 30ml

Parameters	Specification
Formulation	CBD isolate with pharma grade MCT oil
Product Type	MCT oral formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber bottle with glass pipette dropper
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Balanced

15mg/ml CBD – 15mg/ml THC – 30ml

Parameters	Specification
Formulation	Full spectrum THC and CBD extract with pharma grade MCT oil
Product Type	Oral MCT formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber bottle with child-resistant lid and 1ml syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Balanced

25mg/ml CBD – 25mg/ml THC – 30ml

Parameters	Specification
Formulation	Full spectrum THC and CBD extract with pharma grade MCT oil
Product Type	Oral MCT formulation
Appearance	Clear to amber liquid at room temperature
Packaging	30ml amber bottle with child-resistant lid and 1ml syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

THC Dominant

<1mg/ml CBD -15mg/ml THC – 50ml

Parameters	Specification
Formulation	Full spectrum THC extract with pharma grade MCT oil
Product Type	Oral MCT formulation
Appearance	Clear viscous liquid, solid a room temperature
Packaging	50ml amber bottle with child-resistant lid and 1ml syringe
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

THC Dominant

<1mg/ml CBD – 25mg/ml THC – 30ml

Parameters	Specification
Formulation	> 95% THC, minors according to DAC monograph
Product Type	DAC Dronabinol in oily base, MCT-oil formulated according to NRF 22.8
Appearance	Clear viscous liquid, solid a room temperature
Packaging	Insert Argon purged. Amber glass bottle 50ml, 500ml and 2.5L. Glass Type III Polypropylene (PE) Cap
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	12-months
Extraction	Cryo-ethanol extraction Chromatography purification
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

Dronabinol Solution NRF 22.8 25mg/ml

Parameters	Specification
Product Type	DAC Dronabinol in oily base, MCT-Oil Formulated according to NRF 22.8
Formulation	25mg/ml DAC Dronabinol
Appearance	Clear, almost colourless to slightly yellowish viscous solution
Packaging	50ml, 200ml or 500ml amber glass jar Type III, white CR screw cap, magisterial preparation format with TE cap (PP), 2 x THC strip, reaction tube, sterile pipett
Storage	Tightly closed, protected from light, 15 - 25° C
Shelf Life	Ongoing - expected 12 months
Extraction	Solvent extraction and formulation
Origin	South Africa
Stability Status	Conducted according to ICH stability guidelines Long term studies up to: 24 months (25°C±2°C, 60% ± 5%RH) Accelerated studies up to: 6 months (40°C±2°C, 75% ± 5%RH)

GES Monthly Newsletter, April 2024

April 2024